The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia

The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia

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Terry Golombick, Terry DiamondDepartment of Endocrinology, St George Hospital, Kogarah, AustraliaAbstract: Plasma cell dyscrasias, most commonly associated with paraproteinemia, are a diverse group of diseases.Monoclonal g35 coupe fender gammopathy of undefined significance (MGUS) can precede multiple myeloma, a progressive neoplastic disease.MGUS occurs in association with a variety of other diseases and currently no treatment is recommended but rather “watchful waiting”.

Given that the size of the M-protein is a risk factor for disease progression, early intervention with the iphone xr price calgary aim of reducing the paraprotein load would provide an innovative therapeutic tool.Preliminary results from our pilot study show a drop of between 5% and 30% serum paraprotein in patients taking curcumin compared with patients on placebo.Curcumin is a diferuloylmethane present in extracts of the rhizome of the Curcuma longa plant.

As a natural product, this has exciting potential in the treatment of plasma cell dyscrasias.Keywords: plasma cell dyscrasias, MGUS, myeloma, curcumin, paraproteinemia.